What is Parkinson’s Disease?

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder primarily caused by the loss of dopamine-producing neurons in the brain’s substantia nigra. Dopamine is a neurotransmitter critical for coordinating smooth and controlled body movements. As these neurons deteriorate, patients experience symptoms such as tremors, muscle stiffness, bradykinesia (slowness of movement), and postural instability. Non-motor symptoms, including cognitive decline, depression, and sleep disturbances, are also common.

Symptoms of Parkinson’s

Motor Symptoms:

  • Tremors, particularly at rest.
  • Stiffness and rigidity in muscles.
  • Slowness of movement (bradykinesia).
  • Difficulty with balance and coordination.

Non-Motor Symptoms:

  • Mood disorders such as anxiety and depression.
  • Cognitive impairments, including memory loss.
  • Sleep disturbances and fatigue.
  • Gastrointestinal issues, like constipation.

Cell Therapy for Parkinson’s Disease Treatment

Mesenchymal stem cells are multipotent cells capable of promoting repair and regeneration in damaged neural tissues.

Mechanisms of Action

  1. Neuroprotection: MSCs secrete neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), that protect dopamine-producing neurons.
  2. Neurogenesis: MSCs may differentiate into dopaminergic neurons or stimulate endogenous neural stem cells to replace lost neurons.
  3. Anti-Inflammatory Effects: They reduce neuroinflammation, which plays a significant role in the progression of PD.
  4. Mitochondrial Transfer: MSCs can transfer healthy mitochondria to damaged neurons, improving their energy metabolism and function.
  5. Paracrine Effects: MSCs release factors that enhance synaptic connectivity and promote tissue repair.

Benefits of Cell Therapy for Parkinson’s

  • Addresses both motor and non-motor symptoms.
  • Potential to slow disease progression.
  • Improves overall quality of life by restoring neural function.

Take the First Step Towards Relief

If you or a loved one is living with Parkinson’s Disease, our specialists at WIH International Hospital are here to help.

Schedule a consultation to explore how cutting-edge MSC therapy can be part of your personalized treatment plan.